ZFAND5 (NM_001102421) Human Mass Spec Standard

CAT#: PH321129

ZFAND5 MS Standard C13 and N15-labeled recombinant protein (NP_001095891)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description ZFAND5 MS Standard C13 and N15-labeled recombinant protein (NP_001095891)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC221129
Predicted MW 23.1 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_001095891
RefSeq Size 5750
RefSeq ORF 639
Synonyms ZA20D2; ZFAND5A; ZNF216
Locus ID 7763
Cytogenetics 9q21.13
Summary Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.[UniProtKB/Swiss-Prot Function]
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