PR3 (PRTN3) (NM_002777) Human Mass Spec Standard

Specifications

Product Data
Description	PRTN3 MS Standard C13 and N15-labeled recombinant protein (NP_002768)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC220949
Predicted MW	27.6 kDa
Protein Sequence	Sequence Link (showhide) >RC220949 representing NM_002777 Red=Cloning site Green=Tags(s) MAHRPPSPALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTLIHPSFVLTAA HCLRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLNNYDAENKLNDILLIQLSSPANLSASVATVQLP QQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTVVTFFCRPHNICTFVPRRKAGICFGDSGGPLICD GIIQGIDSFVIWGCATRLFPDFFTRVALYVDWIRSTLRRVEAKGRP TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_002768
RefSeq Size	1001
RefSeq ORF	768
Synonyms	ACPA; AGP7; C-ANCA; CANCA; MBN; MBT; NP-4; NP4; P29; PR-3; PR3
Locus ID	5657
Cytogenetics	19p13.3
Summary	Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).[UniProtKB/Swiss-Prot Function]
Protein Families	Druggable Genome, Protease

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