HP1 gamma (CBX3) (NM_016587) Human Mass Spec Standard

Specifications

Product Data
Description	CBX3 MS Standard C13 and N15-labeled recombinant protein (NP_057671)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC220388
Predicted MW	20.8 kDa
Protein Sequence	Sequence Link (showhide) >RC220388 protein sequence Red=Cloning site Green=Tags(s) MASNKTTLQKMGKKQNGKSKKVEEAEPEEFVVEKVLDRRVVNGKVEYFLKWKGFTDADNTWEPEENLDCP ELIEAFLNSQKAGKEKDGTKRKSLSDSESDDSKSKKKRDAADKPRGFARGLDPERIIGATDSSGELMFLM KWKDSDEADLVLAKEANMKCPQIVIAFYEERLTWHSCPEDEAQ TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_057671
RefSeq Size	2102
RefSeq ORF	549
Synonyms	HECH; HP1-GAMMA; HP1Hs-gamma
Locus ID	11335
Cytogenetics	7p15.2
Summary	At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]
Protein Families	Druggable Genome, Transcription Factors

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