PKA R2 (PRKAR2A) (NM_004157) Human Mass Spec Standard

CAT#: PH320376

PRKAR2A MS Standard C13 and N15-labeled recombinant protein (NP_004148)



  View other "PKA R2" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
Transient overexpression lysate of protein kinase, cAMP-dependent, regulatory, type II, alpha (PRKAR2A)
    • 100 ug

CNY 3,080.00


PRKAR2A (PKA R2 ) mouse monoclonal antibody, clone OTI1F8 (formerly 1F8)
    • 100 ul

CNY 1,999.00
CNY 2,700.00

Specifications

Product Data
Description PRKAR2A MS Standard C13 and N15-labeled recombinant protein (NP_004148)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC220376
Predicted MW 45.3 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_004148
RefSeq Size 2381
RefSeq ORF 1212
Synonyms PKR2; PRKAR2
Locus ID 5576
Cytogenetics 3p21.31
Summary cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome
Protein Pathways Apoptosis, Insulin signaling pathway
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