Acid sphingomyelinase (SMPD1) (NM_000543) Human Mass Spec Standard

CAT#: PH319758

SMPD1 MS Standard C13 and N15-labeled recombinant protein (NP_000534)



  View other "Acid sphingomyelinase" proteins (5)

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CNY 14,250.00


货期*
5周

规格
    • 10 ug

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Specifications

Product Data
Description SMPD1 MS Standard C13 and N15-labeled recombinant protein (NP_000534)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC219758
Predicted MW 69.94 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_000534
RefSeq Size 2473
RefSeq ORF 1893
Synonyms ASM; ASMASE; NPD
Locus ID 6609
Cytogenetics 11p15.4
Summary The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2010]
Protein Families Druggable Genome, Transmembrane
Protein Pathways Lysosome, Metabolic pathways, Sphingolipid metabolism
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