Vitamin D Receptor (VDR) (NM_001017535) Human Mass Spec Standard

CAT#: PH319628

VDR MS Standard C13 and N15-labeled recombinant protein (NP_001017535)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description VDR MS Standard C13 and N15-labeled recombinant protein (NP_001017535)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC219628
Predicted MW 48.1 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_001017535
RefSeq Size 4791
RefSeq ORF 1281
Synonyms NR1I1; PPP1R163
Locus ID 7421
Cytogenetics 12q13.11
Summary This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018]
Protein Families Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
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