Pepsin (PGA4) (NM_001079808) Human Mass Spec Standard

Specifications

Product Data
Description	PGA4 MS Standard C13 and N15-labeled recombinant protein (NP_001073276)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC219574
Predicted MW	42 kDa
Protein Sequence	Sequence Link (showhide) >Peptide sequence encoded by RC219574 Blue=ORF Red=Cloning site Green=Tag(s) MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLVDEQPLE NYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSITYG TGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGL VSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIV DTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCI SGFQGMNLPTESGELWILGDVFIRQYFTVFDRANNQVGLAPVA TRTRPLEQKLISEEDLAANDILDYKDDDDKV Recombinant protein using RC219574 also available, TP319574
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_001073276
RefSeq Size	1413
RefSeq ORF	1164
Locus ID	643847
Cytogenetics	11q12.2
Summary	This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]
Protein Families	Druggable Genome

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