RBFOX1 (NM_018723) Human Mass Spec Standard

CAT#: PH317960

A2BP1 MS Standard C13 and N15-labeled recombinant protein (NP_061193)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description A2BP1 MS Standard C13 and N15-labeled recombinant protein (NP_061193)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC217960
Predicted MW 42.6 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_061193
RefSeq Size 2279
RefSeq ORF 1191
Synonyms 2BP1; A2BP1; FOX-1; FOX1; HRNBP1
Locus ID 54715
Cytogenetics 16p13.3
Summary The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
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