alpha A Crystallin (CRYAA) (NM_000394) Human Mass Spec Standard

CAT#: PH316946

CRYAA MS Standard C13 and N15-labeled recombinant protein (NP_000385)



  View other "alpha A Crystallin" proteins (4)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
Transient overexpression lysate of crystallin, alpha A (CRYAA)
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CRYAA mouse monoclonal antibody,clone OTI2C3
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Specifications

Product Data
Description CRYAA MS Standard C13 and N15-labeled recombinant protein (NP_000385)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC216946
Predicted MW 19.9 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_000385
RefSeq Size 1162
RefSeq ORF 519
Synonyms CRYA1; CTRCT9; HSPB4
Locus ID 1409
Cytogenetics 21q22.3
Summary Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC). [provided by RefSeq, Jan 2014]
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