TNNT3 (NM_006757) Human Mass Spec Standard

CAT#: PH316642

TNNT3 MS Standard C13 and N15-labeled recombinant protein (NP_006748)



  View other "TNNT3" proteins (13)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
Rabbit Polyclonal Anti-TNNT3
    • 100 ul

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Transient overexpression lysate of troponin T type 3 (skeletal, fast) (TNNT3), transcript variant 3
    • 100 ug

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Specifications

Product Data
Description TNNT3 MS Standard C13 and N15-labeled recombinant protein (NP_006748)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC216642
Predicted MW 31 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_006748
RefSeq Size 1217
RefSeq ORF 774
Synonyms beta-TnTF; DA2B2; TNTF
Locus ID 7140
Cytogenetics 11p15.5
Summary The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]
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