IL24 (NM_006850) Human Mass Spec Standard

Specifications

Product Data
Description	IL24 MS Standard C13 and N15-labeled recombinant protein (NP_006841)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC216502
Predicted MW	23.8 kDa
Protein Sequence	Sequence Link (showhide) >Peptide sequence encoded by RC216502 Blue=ORF Red=Cloning site Green=Tag(s) MNFQQRLQSLWTLARPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQVKGVVPQKL WEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFS TLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKFYKL TRTRPLEQKLISEEDLAANDILDYKDDDDKV Recombinant protein using RC216502 also available, TP316502M
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_006841
RefSeq Size	1976
RefSeq ORF	618
Synonyms	C49A; FISP; IL10B; MDA7; MOB5; ST16
Locus ID	11009
Cytogenetics	1q32.1
Summary	This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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