BHLHA15 (NM_177455) Human Mass Spec Standard

Specifications

Product Data
Description	BHLHA15 MS Standard C13 and N15-labeled recombinant protein (NP_803238)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC215938
Predicted MW	20.6 kDa
Protein Sequence	Sequence Link (showhide) >RC215938 representing NM_177455 Red=Cloning site Green=Tags(s) MKTKNRPPRRRAPVQDTEATPGEGTPDGSLPNPGPEPAKGLRSRPARAAARAPGEGRRRRPGPSGPGGRR DSSIQRRLESNERERQRMHKLNNAFQALREVIPHVRADKKLSKIETLTLAKNYIKSLTATILTMSSSRLP GLEGPGPKLYQHYQQQQQVAGGALGATEAQPQGHLQRYSTQIHSFREGT TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_803238
RefSeq Size	588
RefSeq ORF	567
Synonyms	BHLHB8; MIST1
Locus ID	168620
Cytogenetics	7q21.3
Summary	Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity).[UniProtKB/Swiss-Prot Function]
Protein Pathways	Maturity onset diabetes of the young

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