MID1 (NM_001098624) Human Mass Spec Standard

CAT#: PH313454

MID1 MS Standard C13 and N15-labeled recombinant protein (NP_001092094)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Transient overexpression lysate of midline 1 (Opitz/BBB syndrome) (MID1), transcript variant 1
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Specifications

Product Data
Description MID1 MS Standard C13 and N15-labeled recombinant protein (NP_001092094)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC213454
Predicted MW 75.1 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_001092094
RefSeq Size 6147
RefSeq ORF 2001
Synonyms BBBG1; FXY; GBBB1; MIDIN; OGS1; OS; OSX; RNF59; TRIM18; XPRF; ZNFXY
Locus ID 4281
Cytogenetics Xp22.2
Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Alternative promoter use, alternative splicing and alternative polyadenylation result in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]
Protein Families Druggable Genome
Protein Pathways Ubiquitin mediated proteolysis
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