Histidine decarboxylase (HDC) (NM_002112) Human Mass Spec Standard

Specifications

Product Data
Description	HDC MS Standard C13 and N15-labeled recombinant protein (NP_002103)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC212698
Predicted MW	74.2 kDa
Protein Sequence	Sequence Link (showhide) >RC212698 protein sequence Red=Cloning site Green=Tags(s) MMEPEEYRERGREMVDYICQYLSTVRERRVMPDVQPGYLRAQLPESAPEDPDSWDSIFGDIERIIMPGVV HWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLGLPEHFLHHHPSS QGGGVLQSTVSESTLIALLAARKNKILEMKTSEPDADESCLNARLVAYASDQAHSSVEKAGLISLVKMKF LPVDDNFSLRGEALQKAIEEDKQRGLVPVFVCATLGTTGVCAFDCLSELGPICAREGLWLHIDAAYAGTA FLCPEFRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGVATDFMHWQ IPLSRRFRSVKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLVVFRLKGPNCLT ENVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIRDAATLILSQHCTSQPSPRVGNL ISQIRGARAWACGTSLQSVSGAGDDPVQARKIIKQPQRVGAGPMKRENGLHLETLLDPVDDCFSEEAPDA TKHKLSSFLFSYLSVQTKKKTVRSLSCNSVPVSAQKPLPTEASVKNGGSSRVRIFSRFPEDMMMLKKSAF KKLIKFYSVPSFPECSSQCGLQLPCCPLQAMV TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_002103
RefSeq Size	2646
RefSeq ORF	1986
Locus ID	3067
Cytogenetics	15q21.2
Summary	This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010]
Protein Families	Druggable Genome
Protein Pathways	Histidine metabolism, Metabolic pathways

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