CD299 (CLEC4M) (NM_214675) Human Mass Spec Standard

CAT#: PH311716

CLEC4M MS Standard C13 and N15-labeled recombinant protein (NP_999840)



  View other "CD299" proteins (7)

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CNY 14,250.00


货期*
5周

规格
    • 10 ug

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Specifications

Product Data
Description CLEC4M MS Standard C13 and N15-labeled recombinant protein (NP_999840)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC211716
Predicted MW 45.4 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_999840
RefSeq Size 1600
RefSeq ORF 1197
Synonyms CD299, LSIGN, CD209L, L-SIGN, DCSIGNR, HP10347, DC-SIGN2, DC-SIGNR, MGC47866, MGC129964
Locus ID 10332
Cytogenetics 19p13.2
Summary This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including tuberculosis mycobacteria, and viruses including Ebola, hepatitis C, HIV-1, influenza A, West Nile virus and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain of variable length, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CD209 (Gene ID: 30835), also known as DC-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression in endothelial cells of the liver, lymph node and placenta. Polymorphisms in the tandem repeat neck domain are associated with resistance to SARS infection. [provided by RefSeq, May 2020]
Protein Families Druggable Genome, Transmembrane
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