Proteasome 20S alpha 5 (PSMA5) (NM_002790) Human Mass Spec Standard

Specifications

Product Data
Description	PSMA5 MS Standard C13 and N15-labeled recombinant protein (NP_002781)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC210717
Predicted MW	26.2 kDa
Protein Sequence	Sequence Link (showhide) >RC210717 representing NM_002790 Red=Cloning site Green=Tags(s) MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSIEKIVEI DAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEEDADPGAMSRPFGVA LLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHKSMTLKEAIKSSLIILKQVMEEKL NATNIELATVQPGQNFHMFTKEELEEVIKDI TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_002781
RefSeq Size	1023
RefSeq ORF	723
Synonyms	PSC5; ZETA
Locus ID	5686
Cytogenetics	1p13.3
Summary	The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Protein Families	Druggable Genome, Protease
Protein Pathways	Proteasome

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