NUDT15 (NM_018283) Human Mass Spec Standard

CAT#: PH310477

NUDT15 MS Standard C13 and N15-labeled recombinant protein (NP_060753)



  View other "NUDT15" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
Transient overexpression lysate of nudix (nucleoside diphosphate linked moiety X)-type motif 15 (NUDT15)
    • 100 ug

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NUDT15 mouse monoclonal antibody,clone OTI4B9
    • 100 ul

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Specifications

Product Data
Description NUDT15 MS Standard C13 and N15-labeled recombinant protein (NP_060753)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC210477
Predicted MW 18.4 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_060753
RefSeq Size 2022
RefSeq ORF 492
Synonyms MTH2; NUDT15D
Locus ID 55270
Cytogenetics 13q14.2
Summary This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016]
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