NUDT15 (NM_018283) Human Mass Spec Standard

Specifications

Product Data
Description	NUDT15 MS Standard C13 and N15-labeled recombinant protein (NP_060753)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC210477
Predicted MW	18.4 kDa
Protein Sequence	Sequence Link (showhide) >RC210477 representing NM_018283 Red=Cloning site Green=Tags(s) MTASAQPRGRRPGVGVGVVVTSCKHPRCVLLGKRKGSVGAGSFQLPGGHLEFGETWEECAQRETWEEAAL HLKNVHFASVVNSFIEKENYHYVTILMKGEVDVTHDSEPKNVEPEKNESWEWVPWEELPPLDQLFWGLRC LKEQGYDPFKEDLNHLVGYKGNHL TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_060753
RefSeq Size	2022
RefSeq ORF	492
Synonyms	MTH2; NUDT15D
Locus ID	55270
Cytogenetics	13q14.2
Summary	This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016]

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