Mannan Binding Lectin (MBL2) (NM_000242) Human Mass Spec Standard

Specifications

Product Data
Description	MBL2 MS Standard C13 and N15-labeled recombinant protein (NP_000233)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC210143
Predicted MW	26.1 kDa
Protein Sequence	Sequence Link (showhide) >RC210143 protein sequence Red=Cloning site Green=Tags(s) MSLFPSLPLLLLSMVAASYSETVTCEDAQKTCPAVIACSSPGINGFPGKDGRDGTKGEKGEPGQGLRGLQ GPPGKLGPPGNPGPSGSPGPKGQKGDPGKSPDGDSSLAASERKALQTEMARIKKWLTFSLGKQVGNKFFL TNGEIMTFEKVKALCVKFQASVATPRNAAENGAIQNLIKEEAFLGITDEKTEGQFVDLTGNRLTYTNWNE GEPNNAGSDEDCVLLLKNGQWNDVPCSTSHLAVCEFPI TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_000233
RefSeq Size	3569
RefSeq ORF	744
Synonyms	COLEC1; HSMBPC; MBL; MBL2D; MBP; MBP-C; MBP1; MBPD
Locus ID	4153
Cytogenetics	10q21.1
Summary	This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes and binds to mannose and N-acetylglucosamine on many microorganisms, including bacteria, yeast, and viruses including influenza virus, HIV and SARS-CoV. This binding activates the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jun 2020]
Protein Families	Druggable Genome
Protein Pathways	Complement and coagulation cascades

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