THEM4 (NM_053055) Human Mass Spec Standard

Specifications

Product Data
Description	THEM4 MS Standard C13 and N15-labeled recombinant protein (NP_444283)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC209396
Predicted MW	26.9 kDa
Protein Sequence	Sequence Link (showhide) >RC209396 representing NM_053055 Red=Cloning site Green=Tags(s) MLRSCAARLRTLGALCRPPVGRRLPGSEPRPELRSFSSEEVILKDCSVPNPSWNKDLRLLFDQFMKKCED GSWKRLPSYKRTPTEWIQDFKTHFLDPKLMKEEQMSQAQLFTRSFDDGLGFEYVMFYNDIEKRMVCLFQG GPYLEGPPGFIHGGAIATMIDATVGMCAMMAGGIVMTANLNINYKRPIPLCSVVMINSQLDKVEGRKFFV SCNVQSVDEKTLYSEATSLFIKLNPAKSLT TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_444283
RefSeq Size	2224
RefSeq ORF	720
Synonyms	CTMP
Locus ID	117145
Cytogenetics	1q21.3
Summary	Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome

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