Myelin Basic Protein (MBP) (NM_001025100) Human Mass Spec Standard

CAT#: PH309071

MBP MS Standard C13 and N15-labeled recombinant protein (NP_001020271)



  View other "Myelin Basic Protein" proteins (21)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description MBP MS Standard C13 and N15-labeled recombinant protein (NP_001020271)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC209071
Predicted MW 21.5 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_001020271
RefSeq Size 4889
RefSeq ORF 591
Locus ID 4155
Cytogenetics 18q23
Summary The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]
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