ORC6L (ORC6) (NM_014321) Human Mass Spec Standard

Specifications

Product Data
Description	ORC6L MS Standard C13 and N15-labeled recombinant protein (NP_055136)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC209054
Predicted MW	28.1 kDa
Protein Sequence	Sequence Link (showhide) >RC209054 protein sequence Red=Cloning site Green=Tags(s) MGSELIGRLAPRLGLAEPDMLRKAEEYLRLSRVKCVGLSARTTETSSAVMCLDLAASWMKCPLDRAYLIK LSGLNKETYQSCLKSFECLLGLNSNIGIRDLAVQFSCIEAVNMASKILKSYESSLPQTQQVDLDLSRPLF TSAALLSACKILKLKVDKNKMVATSGVKKAIFDRLCKQLEKIGQQVDREPGDVATPPRKRKKIVVEAPAK EMEKVEEMPHKPQKDEDLTQDYEEWKRKILENAASAQKATAE TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_055136
RefSeq Size	1644
RefSeq ORF	756
Synonyms	ORC6L
Locus ID	23594
Cytogenetics	16q11.2
Summary	The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]
Protein Families	Druggable Genome, Stem cell - Pluripotency
Protein Pathways	Cell cycle

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