ACTN2 (NM_001103) Human Mass Spec Standard

CAT#: PH308531

ACTN2 MS Standard C13 and N15-labeled recombinant protein (NP_001094)



  View other "ACTN2" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Transient overexpression lysate of actinin, alpha 2 (ACTN2)
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Specifications

Product Data
Description ACTN2 MS Standard C13 and N15-labeled recombinant protein (NP_001094)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC208531
Predicted MW 103.7 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_001094
RefSeq Size 4181
RefSeq ORF 2682
Synonyms CMD1AA; CMH23; MPD6; MYOCOZ
Locus ID 88
Cytogenetics 1q43
Summary Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
Protein Pathways Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Systemic lupus erythematosus, Tight junction
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