NKX2.8 (NKX2-8) (NM_014360) Human Mass Spec Standard

Specifications

Product Data
Description	NKX2 MS Standard C13 and N15-labeled recombinant protein (NP_055175)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC207752
Predicted MW	25.9 kDa
Protein Sequence	Sequence Link (showhide) >RC207752 protein sequence Red=Cloning site Green=Tags(s) MATSGRLSFTVRSLLDLPEQDAQHLPRREPEPRAPQPDPCAAWLDSERGHYPSSDESSLETSPPDSSQRP SARPASPGSDAEKRKKRRVLFSKAQTLELERRFRQQRYLSAPEREQLASLLRLTPTQVKIWFQNHRYKLK RARAPGAAESPDLAASAELHAAPGLLRRVVVPVLVRDGQPCGGGGGGEVGTAAAQEKCGAPPAAACPLPG YPAFGPGSALGLFPAYQHLASPALVSWNW TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_055175
RefSeq Size	1857
RefSeq ORF	717
Synonyms	Nkx2-9; NKX2.8; NKX2H
Locus ID	26257
Cytogenetics	14q13.3
Summary	The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects. [provided by RefSeq, Dec 2015]
Protein Families	Druggable Genome, Transcription Factors

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