TIRAP (NM_001039661) Human Mass Spec Standard
CAT#: PH307162
TIRAP MS Standard C13 and N15-labeled recombinant protein (NP_001034750)
View other "TIRAP" proteins (3)
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CNY 19,520.00
Specifications
Product Data | |
Description | TIRAP MS Standard C13 and N15-labeled recombinant protein (NP_001034750) |
Species | Human |
Expression Host | HEK293 |
Expression cDNA Clone or AA Sequence | RC207162 |
Predicted MW | 28 kDa |
Protein Sequence |
>RC207162 protein sequence
Red=Cloning site Green=Tags(s) MASSTSLPAPGSRPKKPLGKMADWFRQTLLKKPKKRPNSPESTSSDASQPTSQDSPLPPSLSSVTSPSLP PTHASDSGSSRWSKDYDVCVCHSEEDLVAAQDLVSYLEGSTASLRCFLQLRDATPGGAIVSELCQALSSS HCRVLLITPGFLQDPWCKYQMLQALTEAPGAEGCTIPLLSGLSRAAYPPELRFMYYVDGRGPDGGFRQVK EAVMRYLQTLSWHLLYHGTPEIGVKLETENPCRASDSHKCDKRYRE TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Tag | C-Myc/DDK |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration | >0.05 µg/µL as determined by microplate BCA method |
Labeling Method | Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine |
Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
Reference Data | |
RefSeq | NP_001034750 |
RefSeq Size | 2348 |
RefSeq ORF | 666 |
Synonyms | BACTS1; Mal; MyD88-2; wyatt |
Locus ID | 114609 |
Cytogenetics | 11q24.2 |
Summary | The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008] |
Protein Families | Druggable Genome |
Protein Pathways | Toll-like receptor signaling pathway |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC422104 | TIRAP HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LY422104 | Transient overexpression lysate of toll-interleukin 1 receptor (TIR) domain containing adaptor protein (TIRAP), transcript variant 3 |
CNY 3,080.00 |
|
TP307162 | Recombinant protein of human toll-interleukin 1 receptor (TIR) domain containing adaptor protein (TIRAP), transcript variant 3, 20 µg |
CNY 2,900.00 |