Apolipoprotein CIII (APOC3) (NM_000040) Human Mass Spec Standard

Specifications

Product Data
Description	APOC3 MS Standard C13 and N15-labeled recombinant protein (NP_000031)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC206566
Predicted MW	10.9 kDa
Protein Sequence	Sequence Link (showhide) >RC206566 protein sequence Red=Cloning site Green=Tags(s) MQPRVLLVVALLALLASARASEAEDASLLSFMQGYMKHATKTAKDALSSVQESQVAQQARGWVTDGFSSL KDYWSTVKDKFSEFWDLDPEVRPTSAVAA TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_000031
RefSeq Size	533
RefSeq ORF	297
Synonyms	APOCIII
Locus ID	345
Cytogenetics	11q23.3
Summary	This gene encodes a protein component of triglyceride (TG)-rich lipoproteins (TRLs) including very low density lipoproteins (VLDL), high density lipoproteins (HDL) and chylomicrons. The encoded protein plays a role in role in the metabolism of these TRLs through multiple modes. This protein has been shown to promote the secretion of VLDL1, inhibit lipoprotein lipase enzyme activity, and delay catabolism of TRL remnants. Mutations in this gene are associated with low plasma triglyceride levels and reduced risk of ischemic cardiovascular disease, and hyperalphalipoproteinemia, which is characterized by elevated levels of high density lipoprotein (HDL) and HDL cholesterol in human patients. This gene and other related genes comprise an apolipoprotein gene cluster on chromosome 11. [provided by RefSeq, Sep 2017]
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	PPAR signaling pathway

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