PRMT8 (NM_019854) Human Mass Spec Standard

Specifications

Product Data
Description	PRMT8 MS Standard C13 and N15-labeled recombinant protein (NP_062828)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC205188
Predicted MW	45.3 kDa
Protein Sequence	Sequence Link (showhide) >RC205188 protein sequence Red=Cloning site Green=Tags(s) MGMKHSSRCLLLRRKMAENAAESTEVNSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEM TSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGI ECSSISDYSQKIIKANHLDNIITIFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKP GGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDI YTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRR GEEIYGTISMKPNAKNVRDLDFTVDLDFKGQLCETSVSNDYKMR TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_062828
RefSeq Size	2417
RefSeq ORF	1182
Synonyms	HRMT1L3; HRMT1L4
Locus ID	56341
Cytogenetics	12p13.32
Summary	Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008]
Protein Families	Druggable Genome

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