Peroxiredoxin 3 (PRDX3) (NM_006793) Human Mass Spec Standard

Specifications

Product Data
Description	PRDX3 MS Standard C13 and N15-labeled recombinant protein (NP_006784)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC205080
Predicted MW	27.7 kDa
Protein Sequence	Sequence Link (showhide) >RC205080 protein sequence Red=Cloning site Green=Tags(s) MAAAVGRLLRASVARHVSAIPWGISATAALRPAACGRTSLTNLLCSGSSQAKLFSTSSSCHAPAVTQHAP YFKGTAVVNGEFKDLSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSH LAWINTPRKNGGLGHMNIALLSDLTKQISRDYGVLLEGSGLALRGLFIIDPNGVIKHLSVNDLPVGRSVE ETLRLVKAFQYVETHGEVCPANWTPDSPTIKPSPAASKEYFQKVNQ TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_006784
RefSeq Size	1641
RefSeq ORF	768
Synonyms	AOP-1; AOP1; HBC189; MER5; PRO1748; prx-III; SP-22
Locus ID	10935
Cytogenetics	10q26.11
Summary	This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]
Protein Families	Transcription Factors

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