MD2 (LY96) (NM_015364) Human Mass Spec Standard

Specifications

Product Data
Description	LY96 MS Standard C13 and N15-labeled recombinant protein (NP_056179)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC204686
Predicted MW	18.4 kDa
Protein Sequence	Sequence Link (showhide) >RC204686 protein sequence Red=Cloning site Green=Tags(s) MLPFLFFSTLFSSIFTEAQKQYWVCNSSDASISYTYCDKMQYPISINVNPCIELKGSKGLLHIFYIPRRD LKQLYFNLYITVNTMNLPKRKEVICRGSDDDYSFCRALKGETVNTTISFSFKGIKFSKGKYKCVVEAISG SPEEMLFCLEFVILHQPNSN TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_056179
RefSeq Size	642
RefSeq ORF	480
Synonyms	ESOP-1; ly-96; MD-2; MD2
Locus ID	23643
Cytogenetics	8q21.11
Summary	This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]
Protein Families	Secreted Protein
Protein Pathways	Pathogenic Escherichia coli infection, Toll-like receptor signaling pathway

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