C1QB (NM_000491) Human Mass Spec Standard

Specifications

Product Data
Description	C1QB MS Standard C13 and N15-labeled recombinant protein (NP_000482)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC203821
Predicted MW	26.7 kDa
Protein Sequence	Sequence Link (showhide) >RC203821 protein sequence Red=Cloning site Green=Tags(s) MMMKIPWGSIPVLMLLLLLGLIDISQAQLSCTGPPAIPGIPGIPGTPGPDGQPGTPGIKGEKGLPGLAGD HGEFGEKGDPGIPGNPGKVGPKGPMGPKGGPGAPGAPGPKGESGDYKATQKIAFSATRTINVPLRRDQTI RFDHVITNMNNNYEPRSGKFTCKVPGLYYFTYHASSRGNLCVNLMRGRERAQKVVTFCDYAYNTFQVTTG GMVLKLEQGENVFLQATDKNSLLGMEGANSIFSGFLLFPDMEA TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_000482
RefSeq Size	1044
RefSeq ORF	759
Locus ID	713
Cytogenetics	1p36.12
Summary	This gene encodes the B-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. [provided by RefSeq, Dec 2016]
Protein Families	Secreted Protein
Protein Pathways	Complement and coagulation cascades, Prion diseases, Systemic lupus erythematosus

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