WHIP (WRNIP1) (NM_130395) Human Mass Spec Standard

CAT#: PH302950

WRNIP1 MS Standard C13 and N15-labeled recombinant protein (NP_569079)



  View other "WHIP" proteins (5)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Goat Anti-WHIP / WRNIP1 Antibody
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Transient overexpression lysate of Werner helicase interacting protein 1 (WRNIP1), transcript variant 1
    • 100 ug

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Specifications

Product Data
Description WRNIP1 MS Standard C13 and N15-labeled recombinant protein (NP_569079)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC202950
Predicted MW 69.3 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_569079
RefSeq Size 2592
RefSeq ORF 1920
Synonyms bA420G6.2; CFAP93; FAP93; WHIP
Locus ID 56897
Cytogenetics 6p25.2
Summary Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]
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