C1orf41 (HSPB11) (NM_016126) Human Mass Spec Standard

Specifications

Product Data
Description	HSPB11 MS Standard C13 and N15-labeled recombinant protein (NP_057210)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC202693
Predicted MW	16.3 kDa
Protein Sequence	Sequence Link (showhide) >RC202693 protein sequence Red=Cloning site Green=Tags(s) MRKIDLCLSSEGSEVILATSSDEKHPPENIIDGNPETFWTTTGMFPQEFIICFHKHVRIERLVIQSYFVQ TLKIEKSTSKEPVDFEQWIEKDLVHTEGQLQNEEIVAHDGSATYLRFIIVSAFDHFASVHSVSAEGTVVS NLSS TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_057210
RefSeq Size	601
RefSeq ORF	432
Synonyms	C1orf41; FAP232; HSPCO34; IFT25; PP25
Locus ID	51668
Cytogenetics	1p32.3
Summary	Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity).[UniProtKB/Swiss-Prot Function]

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