FKBP25 (FKBP3) (NM_002013) Human Mass Spec Standard

Specifications

Product Data
Description	FKBP3 MS Standard C13 and N15-labeled recombinant protein (NP_002004)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC202200
Predicted MW	25.2 kDa
Protein Sequence	Sequence Link (showhide) >RC202200 protein sequence Red=Cloning site Green=Tags(s) MAAAVPQRAWTVEQLRSEQLPKKDIIKFLQEHGSDSFLAEHKLLGNIKNVAKTANKDHLVTAYNHLFETK RFKGTESISKVSEQVKNVKLNEDKPKETKSEETLDEGPPKYTKSVLKKGDKTNFPKKGDVVHCWYTGTLQ DGTVFDTNIQTSAKKKKNAKPLSFKVGVGKVIRGWDEALLTMSKGEKARLEIEPEWAYGKKGQPDAKIPP NAKLTFEVELVDID TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_002004
RefSeq Size	1353
RefSeq ORF	672
Synonyms	FKBP-3; FKBP-25; FKBP25; PPIase
Locus ID	2287
Cytogenetics	14q21.2
Summary	The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]
Protein Families	Druggable Genome, Stem cell - Pluripotency

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