NBL1 (NM_005380) Human Mass Spec Standard

Specifications

Product Data
Description	NBL1 MS Standard C13 and N15-labeled recombinant protein (NP_005371)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC201954
Predicted MW	19.3 kDa
Protein Sequence	Sequence Link (showhide) >RC201954 protein sequence Red=Cloning site Green=Tags(s) MLRVLVGAVLPAMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACLGQCFSYSVPNT FPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKILHCSCQACGKEPSHEGLSVYVQGEDG PGSQPGTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAED TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_005371
RefSeq Size	2184
RefSeq ORF	540
Synonyms	D1S1733E; DAN; DAND1; NB; NO3
Locus ID	4681
Cytogenetics	1p36.13
Summary	This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013]
Protein Families	Secreted Protein

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