CBS (NM_000071) Human Mass Spec Standard

CAT#: PH301755

CBS MS Standard C13 and N15-labeled recombinant protein (NP_000062)



  View other "CBS" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
Transient overexpression lysate of cystathionine-beta-synthase (CBS)
    • 100 ug

CNY 3,080.00


Rabbit Polyclonal Anti-CBS Antibody
    • 100 ul

CNY 5,250.00

Specifications

Product Data
Description CBS MS Standard C13 and N15-labeled recombinant protein (NP_000062)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC201755
Predicted MW 60.6 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_000062
RefSeq Size 2609
RefSeq ORF 1653
Synonyms CBSL; HIP4
Locus ID 875
Cytogenetics 21q22.3
Summary The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]
Protein Families Druggable Genome
Protein Pathways Cysteine and methionine metabolism, Glycine, serine and threonine metabolism, Metabolic pathways, Selenoamino acid metabolism
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