POLR1D (NM_015972) Human Mass Spec Standard

Specifications

Product Data
Description	POLR1D MS Standard C13 and N15-labeled recombinant protein (NP_057056)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC201466
Predicted MW	15.2 kDa
Protein Sequence	Sequence Link (showhide) >RC201466 protein sequence Red=Cloning site Green=Tags(s) MEEDQELERKISGLKTSMAEGERKTALEMVQAAGTDRHCVTFVLHEEDHTLGNSLRYMIMKNPEVEFCGY TTTHPSESKINLRIQTRGTLPAVEPFQRGLNELMNVCQHVLDKFEASIKDYKDQKASRNESTF TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_057056
RefSeq Size	817
RefSeq ORF	399
Synonyms	AC19; POLR1C; RPA9; RPA16; RPAC2; RPC16; RPO1-3; TCS2
Locus ID	51082
Cytogenetics	13q12.2
Summary	The protein encoded by this gene is a component of the RNA polymerase I and RNA polymerase III complexes, which function in the synthesis of ribosomal RNA precursors and small RNAs, respectively. Mutations in this gene are a cause of Treacher Collins syndrome (TCS), a craniofacial development disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]
Protein Families	Stem cell - Pluripotency, Transcription Factors
Protein Pathways	Cytosolic DNA-sensing pathway, Metabolic pathways, Purine metabolism, Pyrimidine metabolism, RNA polymerase

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