C11orf73 (HIKESHI) (NM_016401) Human Mass Spec Standard

CAT#: PH300866

C11orf73 MS Standard C13 and N15-labeled recombinant protein (NP_057485)



  View other "C11orf73" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
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Specifications

Product Data
Description C11orf73 MS Standard C13 and N15-labeled recombinant protein (NP_057485)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC200866
Predicted MW 21.6 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_057485
RefSeq Size 1187
RefSeq ORF 591
Synonyms C11orf73; HLD13; HSPC138; HSPC179; L7RN6; OPI10
Locus ID 51501
Cytogenetics 11q14.2
Summary This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition of heat shock-induced nuclear accumulation of Hsp70s, indicating a role for this gene in regulation of Hsp70 nuclear import during heat shock stress. [provided by RefSeq, Apr 2016]
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