Superoxide Dismutase 1 (SOD1) (NM_000454) Human Mass Spec Standard

Specifications

Product Data
Description	SOD1 MS Standard C13 and N15-labeled recombinant protein (NP_000445)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC200725
Predicted MW	15.9 kDa
Protein Sequence	Sequence Link (showhide) >RC200725 protein sequence Red=Cloning site Green=Tags(s) MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSR KHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGN AGSRLACGVIGIAQ TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_000445
RefSeq Size	981
RefSeq ORF	462
Synonyms	ALS; ALS1; HEL-S-44; homodimer; hSod1; IPOA; SOD; STAHP
Locus ID	6647
Cytogenetics	21q22.11
Summary	The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. In addition, this protein contains an antimicrobial peptide that displays antibacterial, antifungal, and anti-MRSA activity against E. coli, E. faecalis, S. aureus, S. aureus MRSA LPV+, S. agalactiae, and yeast C. krusei. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2020]
Protein Families	Druggable Genome
Protein Pathways	Amyotrophic lateral sclerosis (ALS), Huntington's disease, Prion diseases

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