United States
Germany
Japan
United Kingdom
China
Glucokinase (GCK) (NM_000162) Human Mass Spec Standard
CAT＃: PH300472
GCK MS Standard C13 and N15-labeled recombinant protein (NP_000153)
View other "Glucokinase" proteins (11)
|
Need it in bulk or customized? Get a free quote |
CNY 19,520.00
Product images
CNY 3,080.00
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Description | GCK MS Standard C13 and N15-labeled recombinant protein (NP_000153) |
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | RC200472 |
| Predicted MW | 52.2 kDa |
| Protein Sequence |
>RC200472 protein sequence
Red=Cloning site Green=Tags(s) MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSE VGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMK HKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATM ISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDES SANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYN ILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Tag | C-Myc/DDK |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Labeling Method | Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
| Reference Data | |
| RefSeq | NP_000153 |
| RefSeq Size | 2741 |
| RefSeq ORF | 1395 |
| Synonyms | FGQTL3; GK; GLK; HHF3; HK4; HKIV; HXKP; LGLK; MODY2; PNDM1 |
| Locus ID | 2645 |
| Cytogenetics | 7p13 |
| Summary | This gene encodes a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. The use of multiple promoters and alternative splicing of this gene result in distinct protein isoforms that exhibit tissue-specific expression in the pancreas and liver. In the pancreas, this enzyme plays a role in glucose-stimulated insulin secretion, while in the liver, this enzyme is important in glucose uptake and conversion to glycogen. Mutations in this gene that alter enzyme activity have been associated with multiple types of diabetes and hyperinsulinemic hypoglycemia. [provided by RefSeq, Aug 2017] |
| Protein Families | Druggable Genome |
| Protein Pathways | Amino sugar and nucleotide sugar metabolism, Galactose metabolism, Glycolysis / Gluconeogenesis, Insulin signaling pathway, Maturity onset diabetes of the young, Metabolic pathways, Starch and sucrose metabolism, Type II diabetes mellitus |
Documents
| FAQs |
| SDS |
Resources
| 蛋白相关资源 |
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| LC400059 | GCK HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC403250 | GCK HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 1,470.00 |
|
| LC409539 | GCK HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 1,470.00 |
|
| LY400059 | Transient overexpression lysate of glucokinase (hexokinase 4) (GCK), transcript variant 1 |
CNY 3,080.00 |
|
| LY403250 | Transient overexpression lysate of glucokinase (hexokinase 4) (GCK), transcript variant 3 |
CNY 4,840.00 |
|
| LY409539 | Transient overexpression lysate of glucokinase (hexokinase 4) (GCK), transcript variant 2 |
CNY 4,840.00 |
|
| PH318920 | GCK MS Standard C13 and N15-labeled recombinant protein (NP_277043) |
CNY 19,520.00 |
|
| PH322793 | GCK MS Standard C13 and N15-labeled recombinant protein (NP_277042) |
CNY 19,520.00 |
|
| TP300472 | Recombinant protein of human glucokinase (hexokinase 4) (GCK), transcript variant 1, 20 µg |
CNY 2,900.00 |
|
| TP318920 | Recombinant protein of human glucokinase (hexokinase 4) (GCK), transcript variant 3, 20 µg |
CNY 2,900.00 |
|
| TP322793 | Recombinant protein of human glucokinase (hexokinase 4) (GCK), transcript variant 2, 20 µg |
CNY 2,900.00 |
其它Glucokinase产品
