RAB7L1 (RAB29) (NM_003929) Human Mass Spec Standard

Specifications

Product Data
Description	RAB7L1 MS Standard C13 and N15-labeled recombinant protein (NP_003920)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC200431
Predicted MW	23.2 kDa
Protein Sequence	Sequence Link (showhide) >RC200431 protein sequence Red=Cloning site Green=Tags(s) MGSRDHLFKVLVVGDAAVGKTSLVQRYSQDSFSKHYKSTVGVDFALKVLQWSDYEIVRLQLWDIAGQERF TSMTRLYYRDASACVIMFDVTNATTFSNSQRWKQDLDSKLTLPNGEPVPCLLLANKCDLSPWAVSRDQID RFSKENGFTGWTETSVKENKNINEAMRVLIEKMMRNSTEDIMSLSTQGDYINLQTKSSSWSCC TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_003920
RefSeq Size	3324
RefSeq ORF	609
Synonyms	RAB7L; RAB7L1
Locus ID	8934
Cytogenetics	1q32.1
Summary	Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection.[UniProtKB/Swiss-Prot Function]
Protein Families	Druggable Genome

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