STUB1 (NM_005861) Human Mass Spec Standard

Specifications

Product Data
Description	STUB1 MS Standard C13 and N15-labeled recombinant protein (NP_005852)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC200310
Predicted MW	34.9 kDa
Protein Sequence	Sequence Link (showhide) >Peptide sequence encoded by RC200310 Blue=ORF Red=Cloning site Green=Tag(s) MKGKEEKEGGARLGAGGGSPEKSPSAQELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALC YLKMQQHEQALADCRRALELDGQSVKAHFFLGQCQLEMESYDEAIANLQRAYSLAKEQRLNFGDDIPSA LRIAKKKRWNSIEERRIHQESELHSYLSRLIAAERERELEECQRNHEGDEDDSHVRAQQACIEAKHDKY MADMDELFSQVDEKRKKRDIPDYLCGKISFELMREPCITPSGITYDRKDIEEHLQRVGHFDPVTRSPLT QEQLIPNLAMKEVIDAFISENGWVEDY SGPTRTRPLEQKLISEEDLAANDILDYKDDDDKV Recombinant protein using RC200310 also available, TP300310
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_005852
RefSeq Size	1650
RefSeq ORF	909
Synonyms	CHIP; HSPABP2; NY-CO-7; SCA48; SCAR16; SDCCAG7; UBOX1
Locus ID	10273
Cytogenetics	16p13.3
Summary	This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2. [provided by RefSeq, Jun 2014]
Protein Families	Druggable Genome
Protein Pathways	Ubiquitin mediated proteolysis

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