TEX264 (NM_015926) Human Mass Spec Standard

CAT#: PH300008

TEX264 MS Standard C13 and N15-labeled recombinant protein (NP_057010)



  View other "TEX264" proteins (5)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description TEX264 MS Standard C13 and N15-labeled recombinant protein (NP_057010)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC200008
Predicted MW 34.2 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_057010
RefSeq Size 1403
RefSeq ORF 939
Synonyms ZSIG11
Locus ID 51368
Cytogenetics 3p21.2
Summary Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537). The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins (PubMed:31006537). Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure (PubMed:31006537).[UniProtKB/Swiss-Prot Function]
Protein Families Secreted Protein, Transmembrane
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