SRMS Human Gene Knockout Kit (CRISPR)

Specifications

Product Data
Format	2 gRNA vectors, 1 GFP-puro donor, 1 scramble control
Donor DNA	GFP-puro
Symbol	SRMS
Locus ID	6725
Kit Components	KN221920G1, SRMS gRNA vector 1 in pCas-Guide CRISPR vector, Target Sequence: GACAAGATCTGGCCGGCGGG KN221920G2, SRMS gRNA vector 2 in pCas-Guide CRISPR vector, Target Sequence: GACCCGGGGGTGCCATGGTC KN221920-D, donor DNA containing left and right homologous arms and GFP-puro functional cassette. Homologous arm and GFP-puro sequences (showhide) pUC vector backbone in gray; Left arm sequence in blue; GFP-puro in green; Right arm in violet ATCTGGCCAA CACTTAAATA AGCAGGCAAT TTTTCACCTG AGTGCAGCTC AGGCTTGGCA ACCACTGCAG GTGCTGAACA GCAGCGCTTC TCCGTGGAAC CCCCACTTCT CCGTGGGCAC GGGCGGCTGT TGGACTGTGG TGCCCTTGGG CATGGGCCAG GCCTGACTGG GCAGAGCCAT TCCGCCTGCC TGGGCCTTGC AGAGGGCGGG AGAGAGGCTG GCCCTGCCCA CCCCGCCCTC CTCGGGCCCC TCCTGGAGCC CGCCCCCGCC CCAGCCCAAG CTGCCCTCTG CCGTCGGGTT GGGGAGGGGA CGGTGCACTC CAGACGCCAA GGAGGTCGAG GACAGGAGGT GCTGTCGGTG TGCCTGAGGC AGGGGGTCCG CCCTGCGCCC CACCCAGCCC CAACGCCAGC CCGGACGCCG GTGGGAACCG TGTGCCTCCT GGATCCAGGG GACCTCTGAG TGACCGCAGG GCCGGGGTCC CCTGTCACCC CACGGCCAGG GCAGGGAGCG CTGGACACCG GGTCCCACCG GCCCTGCCAG TTCCTCTTCC GGGCTCGCGG GCTCCCATGG CCCTCGGGCC CAGCGTGGTG ACCCCGGGGG GAGCCTTGCA GCCCCTTCCC TCAGCTCTTC CTTGCGCTCT ATGACTTCAC GGCGCGGTGT GGCGGGGAGC TGAGTGTCCG CCGCGGGGAC AGGCTCTGTG CCCTCGAAGA GGGGGGCGGC TACATCTTCG CACGCAGGCT TTCGGGCCAG CCCAGCGCCG GGCTCGTGCC CATCACCCAC GTGGCCAAGG CTTCTCCTGA GACGCTCTCA GACCAACCGT GAGTACCTCG GCCTCGGAGT CAGAGCCTGC CTCGCCCCCA GCTGGGGAGT CCAGAACAAC GGCAGGATTT TGAGTTGGAA ATCGCATGTC CGTGGCTATC TGTTCATTCA TTCGTTCATC CACGCATTCA TTCAGGGACA GCTGATGGGC CCCGGGCCGG CAGGTGTGGT AGGAAAACAG CAGTGTCCGC TGTGGGCTGC CGAGAGGGAG AGGAGGCTCC GGCAGGCGTG GTCAGGTCCT GTGGGGGGGA GCATCAGCTG CACCAGCTGG ACACCCAGCA GGCGGTTCCT CCAGGACCCT GCCTGGCTGG CCAGGCCCTC CCGCCCTCAC ACAGGGAGTC CAGTGTTCAT GGATCGGTCA CTGCTTGGAG GGCAGGGGCT GE100003, scramble sequence in pCas-Guide vector
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq	NM_080823
Synonyms	C20orf148; dJ697K14.1; PTK70; SRM
Summary	Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues (PubMed:23822091). Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues (PubMed:29496907). Phosphorylation of KHDRBS1 is EGF-dependent (PubMed:29496907).[UniProtKB/Swiss-Prot Function]

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