NLRP7 Human Gene Knockout Kit (CRISPR)

CAT#: KN215065LP

NLRP7 - human gene knockout kit via CRISPR, HDR mediated




 HDR-mediated knockout kit validation

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CNY 12,260.00


货期*
6周

规格
    • 1 kit

Product images

经常一起买 (3)
pCAS-Scramble, pCas-Guide vector with a scrambled sequence as a negative control (10 µg)
    • 10 ug

CNY 3,710.00


Rabbit Polyclonal Anti-NLRP7 Antibody
    • 100 ul

CNY 1,999.00
CNY 3,280.00


NLRP7 (Myc-DDK-tagged)-Human NLR family, pyrin domain containing 7 (NLRP7), transcript variant 1
    • 10 ug

CNY 7,024.00

Specifications

Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Donor DNA Luciferase-Puro
Symbol NLRP7
Locus ID 199713
Kit Components

KN215065G1, NLRP7 gRNA vector 1 in pCas-Guide CRISPR vector

KN215065G2, NLRP7 gRNA vector 2 in pCas-Guide CRISPR vector

KN215065LP-D, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001127255, NM_139176, NM_206828
Synonyms CLR19.4; HYDM; NALP7; NOD12; PAN7; PYPAF3
Summary This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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