DGKZ Human Gene Knockout Kit (CRISPR)

Specifications

Product Data
Format	2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Donor DNA	RFP-BSD
Symbol	DGKZ
Locus ID	8525
Kit Components	KN205327G1, DGKZ gRNA vector 1 in pCas-Guide CRISPR vector KN205327G2, DGKZ gRNA vector 2 in pCas-Guide CRISPR vector KN205327RB-D, donor DNA containing left and right homologous arms and RFP-BSD functional cassette. GE100003, scramble sequence in pCas-Guide vector
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq	NM_001105540, NM_001199266, NM_001199267, NM_001199268, NM_003646, NM_201532, NM_201533
Synonyms	DAGK5; DAGK6; DGK-ZETA; hDGKzeta
Summary	The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]

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