TENT2 Human Gene Knockout Kit (CRISPR)

Specifications

Product Data
Format	2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Donor DNA	RFP-BSD
Symbol	TENT2
Locus ID	167153
Kit Components	KN203610G1, TENT2 gRNA vector 1 in pCas-Guide CRISPR vector KN203610G2, TENT2 gRNA vector 2 in pCas-Guide CRISPR vector KN203610RB-D, donor DNA containing left and right homologous arms and RFP-BSD functional cassette. GE100003, scramble sequence in pCas-Guide vector
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq	NM_001114393, NM_001114394, NM_001297744, NM_001297745, NM_173797, NM_001349548, NM_001349549, NM_001349550, NM_001349551, NM_001349552, NM_001349553, NM_001349554
Synonyms	GLD2; TUT2
Summary	Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs (PubMed:15070731). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs (PubMed:23200856).[UniProtKB/Swiss-Prot Function]

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