Mouse Tnik activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tnik
Locus ID	665113
Kit Components	GA218319G1, Tnik gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA218319G2, Tnik gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA218319G3, Tnik gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001163007, NM_001163008, NM_001163009, NM_026910
Synonyms	1500031A17Rik; 4831440I19Rik; AI451411; C530008O15Rik; C630040K21Rik
Summary	Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading (By similarity).[UniProtKB/Swiss-Prot Function]

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