Mouse Akap7 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Akap7
Locus ID	432442
Kit Components	GA217477G1, Akap7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA217477G2, Akap7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA217477G3, Akap7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001347460, NM_018747
Synonyms	6430401D08; AI662165; AKAP15; Akap18; BB170514
Summary	Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium (By similarity).[UniProtKB/Swiss-Prot Function]

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