Mouse Unc80 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Unc80
Locus ID	329178
Kit Components	GA216723G1, Unc80 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA216723G2, Unc80 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA216723G3, Unc80 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_175510, NM_001368824, NM_001368825
Synonyms	C030018G13Rik; C230061B10Rik; UNC-80
Summary	Component of the NALCN sodium channel complex, required for channel regulation. This complex is a cation channel activated by neuropeptides substance P, neurotensin, and extracellular calcium that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current. UNC80 is essential for NALCN sensitivity to extracellular calcium.[UniProtKB/Swiss-Prot Function]

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