Mouse Zmiz1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Zmiz1
Locus ID	328365
Kit Components	GA216661G1, Zmiz1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA216661G2, Zmiz1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA216661G3, Zmiz1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001310666, NM_183208
Synonyms	BC065120; E330020C23; ENSMUSG00000072684; Gm10397; I920194n01; Rai17; Zimp10
Summary	Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (By similarity). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (PubMed:26522984).[UniProtKB/Swiss-Prot Function]

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