Mouse Shprh activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Shprh
Locus ID	268281
Kit Components	GA215905G1, Shprh gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA215905G2, Shprh gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA215905G3, Shprh gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001077707, NM_001284354, NM_172937
Synonyms	2610103K11Rik; AA450458; AU024614; BC006883; D230017O13Rik; E130018M05
Summary	E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.[UniProtKB/Swiss-Prot Function]

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